SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. [electronic resource]
Producer: 20030521Description: 2784-8 p. digitalISSN:- 0006-4971
- Adult
- Aged
- Bone Marrow Cells -- pathology
- Carrier Proteins -- genetics
- CpG Islands
- DNA Methylation
- DNA-Binding Proteins -- metabolism
- Feedback, Physiological -- genetics
- Female
- Gene Silencing
- Hematopoietic Stem Cells -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Middle Aged
- Multiple Myeloma -- genetics
- Repressor Proteins
- STAT3 Transcription Factor
- Signal Transduction
- Suppressor of Cytokine Signaling 1 Protein
- Suppressor of Cytokine Signaling Proteins
- Trans-Activators -- metabolism
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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