Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. [electronic resource]
Producer: 20021223Description: 10302-12 p. digitalISSN:- 1529-2401
- Animals
- Aromatic-L-Amino-Acid Decarboxylases -- administration & dosage
- Catecholamines -- metabolism
- Cells, Cultured
- Corpus Striatum -- drug effects
- Disease Models, Animal
- Dopamine -- biosynthesis
- GTP Cyclohydrolase -- administration & dosage
- Gene Expression -- drug effects
- Gene Transfer Techniques
- Genes -- genetics
- Genetic Therapy -- methods
- Genetic Vectors -- administration & dosage
- Humans
- Kidney -- cytology
- Lentivirus -- genetics
- Male
- Neurons -- cytology
- Oxidopamine
- Parkinsonian Disorders -- chemically induced
- Rats
- Rats, Wistar
- Recovery of Function -- drug effects
- Transgenes
- Treatment Outcome
- Tyrosine 3-Monooxygenase -- administration & dosage
No physical items for this record
Publication Type: Journal Article
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