Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors. [electronic resource]
Producer: 20030401Description: 1734-43 p. digitalISSN:- 0006-4971
- Adenoviruses, Human -- genetics
- Animals
- Antibodies, Heterophile -- biosynthesis
- Apolipoprotein C-II
- Apolipoproteins C -- genetics
- Apolipoproteins E -- genetics
- Clodronic Acid -- pharmacology
- DNA, Recombinant -- analysis
- Dog Diseases -- genetics
- Dogs
- Factor VIII -- analysis
- Genes, Synthetic
- Genetic Therapy
- Genetic Vectors -- administration & dosage
- Hemophilia A -- blood
- Hemorrhage -- prevention & control
- Injections, Intravenous
- Liver -- metabolism
- Liver Function Tests
- Macrophages -- drug effects
- Mice
- Mice, Inbred NOD
- Mice, Knockout
- Mice, SCID
- Models, Animal
- Promoter Regions, Genetic
- RNA, Messenger -- biosynthesis
- Species Specificity
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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