Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. [electronic resource]
Producer: 20021224Description: 1781-5 p. digitalISSN:- 1095-9203
- Animals
- Apoptosis
- Brain -- metabolism
- Cell Survival
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors -- pharmacology
- Cytosol -- metabolism
- Glycosylation
- In Situ Nick-End Labeling
- Leupeptins -- pharmacology
- Membrane Proteins -- genetics
- Mice
- Mice, Transgenic
- Multienzyme Complexes -- antagonists & inhibitors
- Nerve Degeneration
- Neurons -- physiology
- PrPSc Proteins -- chemistry
- Presenilin-1
- Prion Diseases -- metabolism
- Prions -- chemistry
- Promoter Regions, Genetic
- Proteasome Endopeptidase Complex
- Protein Conformation
- Protein Folding
- Protein Transport
- Transfection
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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