Myeloperoxidase-generated phenothiazine cation radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase. [electronic resource]
Producer: 20021008Description: 83-94 p. digitalISSN:- 0325-7541
- Amino Acids, Aromatic -- pharmacology
- Animals
- Ascorbic Acid -- pharmacology
- Cations -- pharmacology
- Dihydrolipoamide Dehydrogenase -- antagonists & inhibitors
- Enzyme Inhibitors -- pharmacology
- Free Radical Scavengers -- pharmacology
- Free Radicals
- Humans
- Hydrogen Peroxide -- metabolism
- Peroxidase -- metabolism
- Phenothiazines -- chemistry
- Protozoan Proteins -- antagonists & inhibitors
- Recombinant Fusion Proteins -- antagonists & inhibitors
- Structure-Activity Relationship
- Sulfhydryl Compounds -- pharmacology
- Trypanocidal Agents -- chemistry
- Trypanosoma cruzi -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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