Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. [electronic resource]
Producer: 20020909Description: 551-61 p. digitalISSN:- 0021-9525
- Alzheimer Disease -- genetics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides -- biosynthesis
- Amyloid beta-Protein Precursor -- metabolism
- Aspartic Acid -- genetics
- Aspartic Acid Endopeptidases
- Cell Compartmentation -- physiology
- Cell Membrane -- metabolism
- Cells, Cultured
- Endocytosis -- genetics
- Endopeptidases -- drug effects
- Eukaryotic Cells -- metabolism
- Green Fluorescent Proteins
- Humans
- Indicators and Reagents
- Luminescent Proteins
- Macromolecular Substances
- Membrane Glycoproteins -- metabolism
- Membrane Proteins -- genetics
- Mutagenesis, Site-Directed -- genetics
- Mutation -- physiology
- Presenilin-1
- Protein Binding -- physiology
- Protein Transport -- physiology
- Receptors, Notch
- Recombinant Fusion Proteins -- genetics
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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