Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans. [electronic resource]
Producer: 20020819Description: 3524-30 p. digitalISSN:- 0022-2623
- Animals
- Brain -- metabolism
- Bridged Bicyclo Compounds, Heterocyclic -- chemical synthesis
- CHO Cells
- Combinatorial Chemistry Techniques
- Cricetinae
- Guinea Pigs
- Humans
- In Vitro Techniques
- Ligands
- Morphinans -- chemical synthesis
- Radioligand Assay
- Rats
- Receptors, Opioid, kappa -- antagonists & inhibitors
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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