PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. [electronic resource]
Producer: 20020813Description: 4015-22 p. digitalISSN:- 0008-5472
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Benzimidazoles -- metabolism
- Blood Vessels -- anatomy & histology
- Capillary Permeability -- drug effects
- Carcinoma, Renal Cell -- blood supply
- Enzyme Inhibitors -- pharmacology
- Extravasation of Diagnostic and Therapeutic Materials
- Female
- Fluorescent Dyes -- metabolism
- Heterocyclic Compounds -- blood
- Kidney Neoplasms -- blood supply
- Magnetic Resonance Angiography
- Mice
- Mice, Inbred BALB C
- Neovascularization, Pathologic -- drug therapy
- Organometallic Compounds -- blood
- Phthalazines -- pharmacology
- Pyridines
- Receptor Protein-Tyrosine Kinases -- antagonists & inhibitors
- Receptors, Growth Factor -- antagonists & inhibitors
- Receptors, Vascular Endothelial Growth Factor
- Regional Blood Flow -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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