Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. [electronic resource]
Producer: 20030121Description: 2091-9 p. digitalISSN:- 1078-0432
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Blotting, Northern
- Butadienes -- pharmacology
- Chromones -- pharmacology
- Drug Therapy, Combination
- Enzyme Inhibitors -- pharmacology
- Epidermal Growth Factor -- pharmacology
- Humans
- Immunoblotting
- MAP Kinase Signaling System -- drug effects
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Morpholines -- pharmacology
- Neuregulin-1 -- pharmacology
- Nitriles -- pharmacology
- Paclitaxel -- pharmacology
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Plasmids
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt
- RNA, Messenger -- metabolism
- Tumor Cells, Cultured -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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