Prourokinase mutant that induces highly effective clot lysis without interfering with hemostasis. [electronic resource]
Producer: 20020426Description: 757-63 p. digitalISSN:- 1524-4571
- Amino Acid Substitution
- Animals
- Bleeding Time
- Blood Coagulation -- drug effects
- Disease Models, Animal
- Dogs
- Drug Evaluation, Preclinical
- Drug Stability
- Enzyme Activation -- drug effects
- Femoral Vein -- drug effects
- Fibrin -- drug effects
- Fibrinolysis -- drug effects
- Hemorrhage -- prevention & control
- Hemostasis -- drug effects
- Humans
- Macaca mulatta
- Male
- Mutagenesis, Site-Directed
- Plasma -- drug effects
- Plasminogen -- drug effects
- Recombinant Proteins -- genetics
- Thrombolytic Therapy -- methods
- Thrombosis -- drug therapy
- Tissue Plasminogen Activator -- pharmacology
- Urokinase-Type Plasminogen Activator -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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