Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites. [electronic resource]
Producer: 20021211Description: 1951-9 p. digitalISSN:- 0021-9533
- Animals
- Animals, Newborn
- Binding Sites -- drug effects
- Cell Division -- drug effects
- Cells, Cultured
- Chondroitin Sulfates -- biosynthesis
- Endothelium, Vascular -- drug effects
- Fibroblast Growth Factor 2 -- metabolism
- Gene Expression Regulation, Enzymologic -- drug effects
- Glycosaminoglycans -- metabolism
- Heparitin Sulfate -- biosynthesis
- Humans
- Hypoxia -- enzymology
- Hypoxia-Inducible Factor 1, alpha Subunit
- Neovascularization, Physiologic -- drug effects
- Protein Binding -- drug effects
- Rats
- Receptors, Fibroblast Growth Factor -- drug effects
- Signal Transduction -- drug effects
- Transcription Factors -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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