Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein. [electronic resource]
Producer: 20020418Description: 160-7 p. digitalISSN:- 0022-3565
- Apoproteins -- metabolism
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- chemistry
- Electrophoresis, Polyacrylamide Gel
- Enzyme Inhibitors -- pharmacology
- Escherichia coli -- drug effects
- Ethinyl Estradiol -- pharmacology
- Gas Chromatography-Mass Spectrometry
- Heme -- metabolism
- Mixed Function Oxygenases -- antagonists & inhibitors
- NADP -- metabolism
- Oxidation-Reduction
- Protein Binding -- drug effects
- Solubility
- Spectrometry, Mass, Electrospray Ionization
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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