Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. [electronic resource]
Producer: 20020418Description: 805-15 p. digitalISSN:- 0021-9738
- Animals
- Blood-Retinal Barrier -- drug effects
- Cell Nucleus -- metabolism
- Cells, Cultured
- Culture Media, Conditioned
- DNA-Binding Proteins -- metabolism
- Diabetes Mellitus -- physiopathology
- Diabetic Retinopathy -- physiopathology
- Disease Models, Animal
- Drug Implants
- Endothelial Growth Factors -- genetics
- Glucose -- metabolism
- Humans
- Hypoxia-Inducible Factor 1
- Hypoxia-Inducible Factor 1, alpha Subunit
- Insulin -- pharmacology
- Lymphokines -- genetics
- Male
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Nuclear Proteins -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins -- genetics
- Rats
- Rats, Long-Evans
- Receptor Protein-Tyrosine Kinases -- genetics
- Recombinant Fusion Proteins -- metabolism
- Retina -- cytology
- Transcription Factors -- metabolism
- Transcriptional Activation -- physiology
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factor Receptor-1
- Vascular Endothelial Growth Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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