Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. [electronic resource]
Producer: 20020429Description: 1225-34 p. digitalISSN:- 0013-7227
- Adenoviridae Infections -- pathology
- Animals
- Apoptosis -- physiology
- Cell Death -- drug effects
- Cells, Cultured
- Chemokines -- biosynthesis
- Cytokines -- biosynthesis
- Diabetes Mellitus, Type 1 -- physiopathology
- Fas Ligand Protein
- Insulin -- biosynthesis
- Interferon-gamma -- pharmacology
- Interleukin-1 -- pharmacology
- Islets of Langerhans -- drug effects
- Luciferases -- metabolism
- Male
- Membrane Glycoproteins -- biosynthesis
- NF-kappa B -- physiology
- Poly I-C -- pharmacology
- RNA, Double-Stranded -- physiology
- RNA, Messenger -- biosynthesis
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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