Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. [electronic resource]
Producer: 20020409Description: 1848-58 p. digitalISSN:- 0950-9232
- Apoptosis -- genetics
- Apoptotic Protease-Activating Factor 1
- Caspase 9
- Caspases -- genetics
- Chromosome Deletion
- Chromosomes, Human, Pair 1 -- genetics
- Cytochrome c Group -- metabolism
- DNA Primers -- chemistry
- Enzyme Inhibitors -- pharmacology
- Gene Amplification
- Genes, myc -- genetics
- Humans
- Immunoblotting
- In Situ Hybridization, Fluorescence
- Loss of Heterozygosity
- Microsatellite Repeats
- Neuroblastoma -- genetics
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerases
- Proteins -- genetics
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Staurosporine -- pharmacology
- Transcription, Genetic
- Transduction, Genetic
- Tumor Cells, Cultured -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
- bcl-X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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