The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module. [electronic resource]
Producer: 20020327Description: 2174-84 p. digitalISSN:- 1529-2401
- Active Transport, Cell Nucleus -- drug effects
- Animals
- Apoptosis -- drug effects
- Cells, Cultured
- Corpus Striatum -- cytology
- Disease Models, Animal
- Disease Progression
- Enzyme Activation -- drug effects
- Gene Expression Regulation -- drug effects
- Genes, Dominant
- Huntington Disease -- chemically induced
- In Situ Nick-End Labeling
- JNK Mitogen-Activated Protein Kinases
- Male
- Mitogen-Activated Protein Kinases -- metabolism
- Mutagenesis, Site-Directed
- Neurons -- drug effects
- Nitro Compounds
- Phosphorylation -- drug effects
- Propionates -- toxicity
- Proto-Oncogene Proteins c-jun -- genetics
- Rats
- Rats, Inbred Lew
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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