Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. [electronic resource]
Producer: 20020624Description: 18938-46 p. digitalISSN:- 0021-9258
- Animals
- Down-Regulation
- Epidermal Growth Factor -- antagonists & inhibitors
- ErbB Receptors -- metabolism
- Fibroblasts -- metabolism
- Humans
- Leukocyte Elastase -- metabolism
- Lung -- cytology
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases -- metabolism
- Quinazolines
- RNA, Messenger -- genetics
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
- Tropoelastin -- genetics
- Tyrphostins -- pharmacology
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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