The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). [electronic resource]
Producer: 20020425Description: 175-85 p. digitalISSN:- 1044-7431
- Amino Acid Sequence -- physiology
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides -- biosynthesis
- Amyloid beta-Protein Precursor -- metabolism
- Animals
- Aspartic Acid Endopeptidases -- metabolism
- Brain -- enzymology
- COS Cells
- Dimerization
- Endopeptidases
- Leucine -- metabolism
- Mutation -- physiology
- Phosphorylation
- Protein Structure, Tertiary -- physiology
- Protein Transport -- physiology
- Serine -- metabolism
- Signal Transduction -- physiology
- Up-Regulation -- genetics
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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