Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway. [electronic resource]
Producer: 20020307Description: 36-41 p. digitalISSN:- 0020-7136
- Antineoplastic Agents -- pharmacology
- Cell Movement -- drug effects
- Cells, Cultured
- Down-Regulation
- Endothelial Growth Factors -- antagonists & inhibitors
- Endothelium, Vascular -- cytology
- Fibroblast Growth Factor 2 -- antagonists & inhibitors
- Humans
- Lymphokines -- antagonists & inhibitors
- Matrix Metalloproteinase 9 -- physiology
- Mitogen-Activated Protein Kinases -- physiology
- Phosphatidylinositol 3-Kinases -- physiology
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- physiology
- Proto-Oncogene Proteins c-akt
- Topotecan -- pharmacology
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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