Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. [electronic resource]
Producer: 20020305Description: 773-80 p. digitalISSN:- 0008-5472
- Adenoviridae -- genetics
- Animals
- Antimetabolites, Antineoplastic -- pharmacokinetics
- Brain Neoplasms -- drug therapy
- Cytosine Deaminase
- Flucytosine -- administration & dosage
- Fluorouracil -- pharmacokinetics
- Genetic Therapy -- methods
- Genetic Vectors -- administration & dosage
- Glioblastoma -- drug therapy
- Humans
- Injections, Intralesional
- Mice
- Mice, SCID
- Nucleoside Deaminases -- genetics
- Prodrugs -- pharmacokinetics
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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