CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. [electronic resource]
Producer: 20020731Description: 1-17 p. digitalISSN:- 0049-8254
- Adult
- Biological Availability
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- genetics
- DNA, Complementary -- genetics
- Enzyme Inhibitors -- pharmacology
- Female
- Gene Expression
- HIV Protease Inhibitors -- chemistry
- Humans
- In Vitro Techniques
- Indinavir -- pharmacology
- Ketoconazole -- pharmacology
- Kinetics
- Magnetic Resonance Spectroscopy
- Male
- Mass Spectrometry
- Microsomes, Liver -- drug effects
- Mixed Function Oxygenases -- antagonists & inhibitors
- Nelfinavir -- pharmacology
- Ritonavir -- pharmacology
- Saquinavir -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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