The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. [electronic resource]
Producer: 20020328Description: 249-59 p. digitalISSN:- 0021-9525
- Animals
- Blotting, Western
- CDC2 Protein Kinase -- antagonists & inhibitors
- Cell Cycle Proteins -- chemistry
- Cell Line
- Cell-Free System
- Enzyme Activation
- G2 Phase
- Humans
- Ligases -- chemistry
- Maturation-Promoting Factor -- metabolism
- Mitosis
- Neoplasm Proteins
- Phosphorylation
- Phosphotyrosine -- metabolism
- Poly-ADP-Ribose Binding Proteins
- Protein Kinases -- metabolism
- Protein Processing, Post-Translational
- Protein Serine-Threonine Kinases -- metabolism
- Protein Structure, Tertiary
- Proto-Oncogene Proteins
- Ubiquitin -- metabolism
- Ubiquitin-Protein Ligases
- Xenopus
- Xenopus Proteins
- Polo-Like Kinase 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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