Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites. [electronic resource]
Producer: 20020225Description: 549-58 p. digitalISSN:- 0022-3565
- Animals
- Aryl Hydrocarbon Hydroxylases
- Biotransformation
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2B1 -- antagonists & inhibitors
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- biosynthesis
- Enzyme Induction -- drug effects
- Ethinyl Estradiol -- analogs & derivatives
- Humans
- In Vitro Techniques
- Isoenzymes -- antagonists & inhibitors
- Liver -- drug effects
- Male
- NADPH-Ferrihemoprotein Reductase -- isolation & purification
- Oxidoreductases, N-Demethylating -- antagonists & inhibitors
- Phenobarbital -- pharmacology
- Rats
- Rats, Long-Evans
- Spectrophotometry, Ultraviolet
- Steroid Hydroxylases -- antagonists & inhibitors
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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