Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine. [electronic resource]
Producer: 20020212Description: 439-45 p. digitalISSN:- 0020-7136
- Adenocarcinoma -- pathology
- Antimetabolites, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- pathology
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins -- biosynthesis
- DNA Damage
- DNA Replication -- drug effects
- DNA, Neoplasm -- drug effects
- Deoxycytidine -- analogs & derivatives
- Drug Resistance, Neoplasm -- genetics
- Female
- G1 Phase -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, Dominant
- Genes, bcl-2
- Genes, p53
- Humans
- Neoplasm Proteins -- deficiency
- Neoplastic Stem Cells -- drug effects
- Phenotype
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- RNA, Messenger -- biosynthesis
- RNA, Neoplasm -- biosynthesis
- S Phase -- drug effects
- Tumor Cells, Cultured -- drug effects
- Tumor Suppressor Protein p53 -- deficiency
- bcl-X Protein
- Gemcitabine
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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