The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth. [electronic resource]
Producer: 20020411Description: 267-74 p. digitalISSN:- 1078-0432
- Angiogenesis Inhibitors -- therapeutic use
- Animals
- Anticarcinogenic Agents -- therapeutic use
- Cell Division -- drug effects
- Dose-Response Relationship, Drug
- Endothelium, Vascular -- drug effects
- Hemangiosarcoma -- blood supply
- Humans
- Insulin-Like Growth Factor I -- metabolism
- Liver -- metabolism
- Male
- Mice
- Mice, Nude
- Neovascularization, Pathologic -- drug therapy
- Oligonucleotide Array Sequence Analysis -- methods
- Pyrazines -- therapeutic use
- Rats
- Receptor Protein-Tyrosine Kinases -- metabolism
- Receptor, Fibroblast Growth Factor, Type 4
- Receptors, Fibroblast Growth Factor -- metabolism
- Receptors, Growth Factor -- metabolism
- Receptors, Vascular Endothelial Growth Factor
- Ribonuclease, Pancreatic -- metabolism
- Thiones
- Thiophenes
- Transplantation, Heterologous
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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