Malignant glioma cells use MHC class II transactivator (CIITA) promoters III and IV to direct IFN-gamma-inducible CIITA expression and can function as nonprofessional antigen presenting cells in endocytic processing and CD4(+) T-cell activation. [electronic resource]
Producer: 20020122Description: 391-405 p. digitalISSN:- 0894-1491
- Adult
- Antigen Presentation -- genetics
- Antigen-Presenting Cells -- cytology
- Antigens, Surface -- genetics
- Astrocytes -- cytology
- Autoantigens -- immunology
- Base Sequence -- genetics
- Brain Neoplasms -- immunology
- CD4-Positive T-Lymphocytes -- cytology
- Exons -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- genetics
- Glioma -- immunology
- Histocompatibility Antigens Class II -- immunology
- Humans
- Immunohistochemistry
- Interferon-gamma -- immunology
- Male
- Middle Aged
- Molecular Sequence Data
- Myelin Basic Protein -- immunology
- Nuclear Proteins
- Promoter Regions, Genetic -- genetics
- RNA, Messenger -- immunology
- Trans-Activators -- genetics
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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