The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations. [electronic resource]
Producer: 20020321Description: 4989-98 p. digitalISSN:- 0021-9258
- Anti-Arrhythmia Agents -- pharmacology
- Astemizole -- pharmacology
- Benzimidazoles -- pharmacology
- Binding Sites
- Blotting, Western
- Cation Transport Proteins
- Cell Line
- Cell Membrane -- metabolism
- Cisapride -- pharmacology
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- ERG1 Potassium Channel
- Electrophysiology
- Ether-A-Go-Go Potassium Channels
- Gastrointestinal Agents -- pharmacology
- Histamine H1 Antagonists -- pharmacology
- Humans
- Inhibitory Concentration 50
- Ions
- Long QT Syndrome -- genetics
- Models, Chemical
- Mutagenesis, Site-Directed
- Mutation
- Patch-Clamp Techniques
- Piperidines -- pharmacology
- Potassium Channels -- chemistry
- Potassium Channels, Voltage-Gated
- Protein Folding
- Pyridines -- pharmacology
- Quaternary Ammonium Compounds -- chemistry
- Quinidine -- pharmacology
- Structure-Activity Relationship
- Trans-Activators
- Transcriptional Regulator ERG
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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