Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340). [electronic resource]
Producer: 20020204Description: 717-24 p. digitalISSN:- 1044-1549
- ADAM Proteins
- ADAM17 Protein
- Acute Disease
- Animals
- Antigens, CD
- Antigens, Neoplasm
- Antineoplastic Agents -- administration & dosage
- Barotrauma -- drug therapy
- Basigin
- Capillary Permeability
- Culture Media, Conditioned
- Drug Evaluation, Preclinical
- Enzyme Induction
- Enzyme Inhibitors -- administration & dosage
- Fibroblasts -- drug effects
- Injections, Intraperitoneal
- Lung -- enzymology
- Lung Injury
- Matrix Metalloproteinase 2 -- metabolism
- Matrix Metalloproteinase 9 -- metabolism
- Matrix Metalloproteinase Inhibitors
- Membrane Glycoproteins -- antagonists & inhibitors
- Metalloendopeptidases -- antagonists & inhibitors
- Models, Animal
- Organic Chemicals
- Positive-Pressure Respiration -- adverse effects
- Premedication
- Pressure
- Rats
- Rats, Sprague-Dawley
- Respiratory Distress Syndrome -- etiology
- Stress, Mechanical
- Tumor Necrosis Factor-alpha -- biosynthesis
- Ventilators, Mechanical
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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