Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. [electronic resource]
Producer: 20011212Description: 8062-7 p. digitalISSN:- 0008-5472
- Adult
- Base Sequence
- Checkpoint Kinase 2
- Colonic Neoplasms -- genetics
- DNA, Complementary -- genetics
- Female
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Genes, p53 -- genetics
- Humans
- Li-Fraumeni Syndrome -- enzymology
- Loss of Heterozygosity
- Male
- Molecular Sequence Data
- Mutation, Missense
- Pedigree
- Protein Kinases -- genetics
- Protein Serine-Threonine Kinases
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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