Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. [electronic resource]
Producer: 20020111Description: 9246-54 p. digitalISSN:- 1529-2401
- Amino Acid Substitution
- Amino Acids -- cerebrospinal fluid
- Amyotrophic Lateral Sclerosis -- genetics
- Animals
- Apoptosis
- Caspases -- metabolism
- Disease Models, Animal
- Disease Progression
- Enzyme Activation -- genetics
- Female
- Humans
- Mice
- Microinjections
- Motor Neurons -- pathology
- Mutation
- Neuropil -- pathology
- Phenotype
- Rats
- Rats, Sprague-Dawley
- Spinal Cord -- pathology
- Superoxide Dismutase -- biosynthesis
- Superoxide Dismutase-1
- Transgenes
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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