Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates. [electronic resource]
Producer: 20020130Description: 6108-14 p. digitalISSN:- 0020-1669
- Animals
- Antineoplastic Agents -- chemical synthesis
- Carbamates -- chemistry
- Catalysis
- Chromatography, High Pressure Liquid
- Female
- Humans
- Hydrogen-Ion Concentration
- Hydrolysis
- Inhibitory Concentration 50
- Leukemia L1210
- Mice
- Molecular Structure
- Nuclear Magnetic Resonance, Biomolecular
- Organoplatinum Compounds -- chemical synthesis
- Ovarian Neoplasms
- Polyamines -- chemical synthesis
- Prodrugs -- chemical synthesis
- Spermidine -- chemistry
- Spermine -- chemistry
- Stereoisomerism
- Structure-Activity Relationship
- Temperature
- Tumor Cells, Cultured -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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