IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. [electronic resource]
Producer: 20011204Description: 4361-72 p. digitalISSN:- 1362-4962
- Animals
- Base Sequence
- Chondrocytes -- drug effects
- Collagenases -- biosynthesis
- Core Binding Factor Alpha 1 Subunit
- Core Binding Factor alpha Subunits
- DNA-Binding Proteins -- chemistry
- Drosophila Proteins
- Fibroblasts
- Genes, Reporter -- genetics
- Humans
- Imidazoles -- pharmacology
- Interleukin-1 -- pharmacology
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 3
- MAP Kinase Kinase Kinase 1
- MAP Kinase Signaling System -- drug effects
- Matrix Metalloproteinase 13
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Mitogen-Activated Protein Kinases -- metabolism
- Molecular Sequence Data
- Mutation -- genetics
- NF-kappa B -- metabolism
- Neoplasm Proteins
- Nuclear Proteins
- Promoter Regions, Genetic -- genetics
- Protein Serine-Threonine Kinases -- genetics
- Protein Structure, Tertiary
- Protein-Tyrosine Kinases -- metabolism
- Pyridines -- pharmacology
- RNA, Messenger -- genetics
- Response Elements -- genetics
- Transcription Factor AP-1 -- metabolism
- Transcription Factors -- genetics
- Tumor Cells, Cultured
- Up-Regulation -- drug effects
- p38 Mitogen-Activated Protein Kinases
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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