The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. [electronic resource]
Producer: 20011204Description: 7525-9 p. digitalISSN:- 0008-5472
- 3T3 Cells -- drug effects
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- antagonists & inhibitors
- Adenosine Triphosphate -- metabolism
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- pharmacology
- Biological Transport, Active -- drug effects
- CHO Cells
- Cell Line
- Cricetinae
- Daunorubicin -- pharmacokinetics
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Farnesyltranstransferase
- Genes, MDR
- Humans
- Hydrolysis
- Mice
- Paclitaxel -- pharmacology
- Piperidines -- pharmacology
- Pyridines -- pharmacology
- Rhodamine 123 -- pharmacokinetics
- Tamoxifen -- pharmacology
- Vinblastine -- pharmacology
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Publication Type: Journal Article
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