Identification of determinants of inverse agonism in a constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor by photoaffinity cross-linking and mutational analysis. [electronic resource]
Producer: 20011226Description: 42692-9 p. digitalISSN:- 0021-9258
- Animals
- COS Cells
- Cattle
- Cross-Linking Reagents -- pharmacology
- Cyclic AMP -- metabolism
- DNA Mutational Analysis
- Dose-Response Relationship, Drug
- Electrophoresis, Polyacrylamide Gel
- Humans
- Inhibitory Concentration 50
- Leucine -- chemistry
- Ligands
- Mass Spectrometry
- Methionine -- chemistry
- Models, Biological
- Mutagenesis, Site-Directed
- Mutation
- Parathyroid Hormone -- agonists
- Peptides -- chemistry
- Plasmids -- metabolism
- Protein Binding
- Protein Structure, Tertiary
- Rats
- Receptors, Parathyroid Hormone -- agonists
- Transfection
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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