The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis. [electronic resource]
Producer: 20011025Description: 311-8 p. digitalISSN:- 1465-9905
- Adult
- Camptothecin -- pharmacokinetics
- Cells, Cultured
- Collagen -- biosynthesis
- Culture Media, Conditioned -- chemistry
- Dose-Response Relationship, Drug
- Elastin -- biosynthesis
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Extracellular Matrix -- chemistry
- Female
- Fibroblasts -- drug effects
- Humans
- Male
- Procollagen -- biosynthesis
- RNA, Messenger -- metabolism
- Scleroderma, Systemic -- metabolism
- Skin -- cytology
- Topoisomerase I Inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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