Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage. [electronic resource]
Producer: 20011205Description: 517-30 p. digitalISSN:- 0223-5234
- Animals
- Anti-Inflammatory Agents -- adverse effects
- Benzamides -- adverse effects
- Cyclooxygenase 1
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- adverse effects
- Drug Design
- Drug Evaluation, Preclinical
- Edema -- chemically induced
- Food Deprivation
- Inhibitory Concentration 50
- Isoenzymes -- antagonists & inhibitors
- Magnetic Resonance Spectroscopy
- Male
- Membrane Proteins
- Prostaglandin-Endoperoxide Synthases -- metabolism
- Rats
- Rats, Wistar
- Sheep
- Stomach -- drug effects
- Structure-Activity Relationship
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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