Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. [electronic resource]
Producer: 20011205Description: 2911-20 p. digitalISSN:- 0022-1767
- 5'-Nucleotidase -- antagonists & inhibitors
- Adenosine -- metabolism
- Adenosine Triphosphate -- analogs & derivatives
- Base Sequence
- DNA-Binding Proteins -- metabolism
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Folic Acid Antagonists -- pharmacology
- Gene Expression -- drug effects
- Genes, Reporter -- drug effects
- HeLa Cells
- Humans
- I-kappa B Kinase
- I-kappa B Proteins
- Jurkat Cells
- Leucovorin -- pharmacology
- Methotrexate -- pharmacology
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- Oligodeoxyribonucleotides -- genetics
- Phosphorylation
- Protein Serine-Threonine Kinases -- metabolism
- Purinergic P1 Receptor Antagonists
- Receptor, Adenosine A2B
- Theobromine -- analogs & derivatives
- Thymidine -- pharmacology
- Transcription Factor AP-1 -- metabolism
- Tumor Necrosis Factor-alpha -- pharmacology
- U937 Cells
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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