Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. [electronic resource]
Producer: 20011204Description: 39411-8 p. digitalISSN:- 0021-9258
- ATP Binding Cassette Transporter, Subfamily B, Member 11
- ATP-Binding Cassette Transporters -- biosynthesis
- Amino Acid Sequence
- Animals
- Base Sequence
- Bile Acids and Salts -- metabolism
- Cell Line
- Cell Nucleus -- metabolism
- Cells, Cultured
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- chemistry
- Dimerization
- Dose-Response Relationship, Drug
- Down-Regulation
- Genes, Reporter
- Hepatocytes -- metabolism
- Humans
- Immunoblotting
- Ligands
- Liver -- metabolism
- Luciferases -- metabolism
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Mixed Function Oxygenases -- metabolism
- Molecular Sequence Data
- Multidrug Resistance-Associated Proteins -- metabolism
- Plasmids -- metabolism
- Promoter Regions, Genetic
- Protein Binding
- Protein Structure, Tertiary
- Reverse Transcriptase Polymerase Chain Reaction
- Ribosomal Proteins -- metabolism
- Sequence Homology, Nucleic Acid
- Transfection
- Up-Regulation
- Ursodeoxycholic Acid -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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