Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. [electronic resource]
Producer: 20010906Description: 2687-90 p. digitalISSN:- 0022-2623
- Animals
- Binding, Competitive
- Brain -- metabolism
- Cloning, Molecular
- Guinea Pigs
- Humans
- In Vitro Techniques
- Isoquinolines -- chemical synthesis
- Narcotic Antagonists -- chemical synthesis
- Piperidines -- chemical synthesis
- Radioligand Assay
- Rats
- Receptors, Opioid, delta -- antagonists & inhibitors
- Receptors, Opioid, kappa -- antagonists & inhibitors
- Receptors, Opioid, mu -- antagonists & inhibitors
- Structure-Activity Relationship
- Tetrahydroisoquinolines
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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