Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells. [electronic resource]
Producer: 20011204Description: 37747-53 p. digitalISSN:- 0021-9258
- Antineoplastic Agents -- pharmacology
- Benzamides
- Carbon -- metabolism
- Enzyme Inhibitors -- pharmacology
- Fatty Acids -- biosynthesis
- Glucose -- metabolism
- Glucosephosphate Dehydrogenase -- metabolism
- Hexokinase -- metabolism
- Humans
- Imatinib Mesylate
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- enzymology
- Nucleic Acids -- biosynthesis
- Piperazines -- pharmacology
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Pyrimidines -- pharmacology
- Transketolase -- metabolism
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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