The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. [electronic resource]
Producer: 20010830Description: 5847-53 p. digitalISSN:- 1529-2401
- Administration, Oral
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Carrageenan
- Cyclooxygenase 1
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- administration & dosage
- Dinoprostone -- biosynthesis
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Hyperalgesia -- chemically induced
- Ibuprofen -- administration & dosage
- Injections, Intraperitoneal
- Injections, Spinal
- Isoenzymes -- antagonists & inhibitors
- Male
- Membrane Proteins
- N-Methylaspartate
- Pain Measurement -- drug effects
- Prostaglandin-Endoperoxide Synthases -- metabolism
- Pyrazoles -- administration & dosage
- Rats
- Rats, Sprague-Dawley
- Spinal Cord -- drug effects
- Substance P
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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