Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. [electronic resource]
Producer: 20010802Description: 441-52 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Biopolymers
- Cell-Free System
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- Enzyme Precursors -- antagonists & inhibitors
- ErbB Receptors -- antagonists & inhibitors
- Humans
- Inhibitory Concentration 50
- Intracellular Signaling Peptides and Proteins
- Mice
- Phenols -- chemical synthesis
- Phosphorylation
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Structure-Activity Relationship
- Syk Kinase
- Tubulin -- chemistry
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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