Generation of a mouse with low galactocerebrosidase activity by gene targeting: a new model of globoid cell leukodystrophy (Krabbe disease). [electronic resource]
Producer: 20011004Description: 211-23 p. digitalISSN:- 1096-7192
- Age Factors
- Alleles
- Animals
- Blotting, Northern
- Body Weight
- Brain -- metabolism
- COS Cells
- Codon
- DNA, Complementary -- metabolism
- Disease Models, Animal
- Electroporation
- Galactosylceramidase -- genetics
- Gene Targeting
- Genetic Vectors
- Homozygote
- Humans
- Leukodystrophy, Globoid Cell -- genetics
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Models, Genetic
- Mutation
- Polymorphism, Genetic
- Psychosine -- biosynthesis
- Recombinant Proteins -- genetics
- Recombination, Genetic
- Reverse Transcriptase Polymerase Chain Reaction
- Time Factors
- Tissue Distribution
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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