Induction of bulk and c-myc P2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells. [electronic resource]
Producer: 20010809Description: 59-64 p. digitalISSN:- 0014-5793
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Cell Division -- drug effects
- DNA Damage -- drug effects
- DNA Fragmentation -- drug effects
- DNA Topoisomerases, Type II -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Gene Expression Regulation -- drug effects
- Genes, fos -- genetics
- Genes, jun -- genetics
- Genes, myc -- genetics
- HL-60 Cells
- Humans
- Naphthoquinones -- chemistry
- Promoter Regions, Genetic -- genetics
- RNA Stability -- drug effects
- RNA, Messenger -- genetics
- Substrate Specificity
- Topoisomerase II Inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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