Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3). [electronic resource]
Producer: 20010913Description: 1280-8 p. digitalISSN:- 0002-7863
- Angiogenesis Inhibitors -- analysis
- Animals
- Combinatorial Chemistry Techniques
- Humans
- Matrix Metalloproteinase 2 -- metabolism
- Matrix Metalloproteinase Inhibitors
- Models, Chemical
- Neovascularization, Pathologic -- physiopathology
- Neovascularization, Physiologic -- physiology
- Peptide Library
- Protein Binding
- Receptors, Vitronectin -- metabolism
- Solubility
- Vitronectin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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