Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. [electronic resource]
Producer: 20010802Description: 5349-54 p. digitalISSN:- 0008-5472
- Animals
- Antibodies, Monoclonal -- pharmacology
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Brain Neoplasms -- drug therapy
- Cell Division -- drug effects
- Down-Regulation -- drug effects
- ErbB Receptors -- genetics
- Gene Expression Regulation, Neoplastic
- Glioblastoma -- drug therapy
- Humans
- In Situ Nick-End Labeling
- Mice
- Mice, Nude
- Mutation
- Neovascularization, Pathologic -- prevention & control
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- drug effects
- Survival Analysis
- Survival Rate
- Transplantation, Heterologous
- Treatment Outcome
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
- bcl-X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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