In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine I-carboxamide). [electronic resource]
Producer: 20010920Description: 53-63 p. digitalISSN:- 0306-5251
- Adolescent
- Adult
- Antiviral Agents -- metabolism
- Biotransformation
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP1A2 Inhibitors
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Cytomegalovirus -- drug effects
- Drug Interactions
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Indinavir -- metabolism
- Indolizines -- metabolism
- Male
- Microsomes, Liver -- enzymology
- Middle Aged
- Mixed Function Oxygenases -- antagonists & inhibitors
- Molecular Structure
- Pyridines -- metabolism
- Yeasts -- enzymology
- Zidovudine -- metabolism
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Publication Type: Journal Article
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