Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia. [electronic resource]
Producer: 20010802Description: 3197-201 p. digitalISSN:- 0021-972X
- Adrenal Hyperplasia, Congenital -- blood
- Aldosterone -- blood
- Androstenedione -- blood
- Animals
- Blotting, Southern
- COS Cells
- Child, Preschool
- Cortodoxone -- blood
- Crossing Over, Genetic
- Cyproterone Acetate -- therapeutic use
- Cytochrome P-450 CYP11B2 -- genetics
- DNA, Complementary -- genetics
- Exons
- Gene Deletion
- Gene Expression
- Homozygote
- Humans
- Male
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Puberty, Precocious -- drug therapy
- Renin -- blood
- Steroid 11-beta-Hydroxylase -- genetics
- Transfection
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Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
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