Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. [electronic resource]
Producer: 20010906Description: 30018-23 p. digitalISSN:- 0021-9258
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor -- metabolism
- Animals
- Aspartic Acid Endopeptidases
- Binding, Competitive
- Biotinylation
- Blotting, Western
- Cell Nucleus -- metabolism
- Culture Media, Conditioned -- pharmacology
- Dose-Response Relationship, Drug
- Endopeptidases -- metabolism
- Enzyme Activation
- Enzyme-Linked Immunosorbent Assay
- Humans
- Immunoblotting
- Ligands
- Luciferases -- metabolism
- Membrane Proteins -- metabolism
- Mice
- Mice, Transgenic
- Models, Biological
- Neurons -- metabolism
- Presenilin-1
- Protein Binding
- Protein Structure, Tertiary
- Receptor, Notch1
- Receptors, Cell Surface
- Time Factors
- Transcription Factors
- Transfection
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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