Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. [electronic resource]
Producer: 20010823Description: 7486-95 p. digitalISSN:- 0022-1767
- Apoptosis -- drug effects
- Cell Survival -- drug effects
- Cells, Cultured
- DNA-Binding Proteins -- genetics
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Granulocyte-Macrophage Colony-Stimulating Factor -- physiology
- Humans
- Janus Kinase 1
- Janus Kinase 2
- Janus Kinase 3
- Kinetics
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- biosynthesis
- Neutrophils -- cytology
- Oligonucleotides, Antisense -- pharmacology
- Phosphatidylinositol 3-Kinases -- physiology
- Precipitin Tests
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA, Messenger -- biosynthesis
- STAT3 Transcription Factor
- Signal Transduction -- drug effects
- Trans-Activators -- genetics
- Tyrphostins -- pharmacology
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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